Tabriz University of Medical Sciences Spirituality Research in Health Sciences 3041-8569 3 2 2026 03 14 The role of spiritual beliefs in reducing anxiety in patients undergoing rehabilitation after stroke: a narrative review 115 125 10.34172/srhs.2025.011 EN Hakimeh Adigozali https://orcid.org/0000-0001-8784-8992 Zeinab Fathipour-Azar https://orcid.org/0000-0001-7354-5157 Fatemeh Fekar Gharamaleki https://orcid.org/0000-0001-8327-9497 Journal Article 10.34172/srhs.2025.011 2026 05 06 2026 05 09 Background. Stroke is the leading cause of disability worldwide, with 50% of patients experiencing clinical anxiety post-stroke, which significantly hampers rehabilitation. This narrative review examines the role of spiritual beliefs in reducing anxiety among these patients. Methods. A literature search was conducted in SID, PubMed, Scopus, Web of Science, MagIran, and Google Scholar from 2011 to 2025 using relevant Persian and English keywords. Results. Based on 18 included studies, the review indicates that spirituality positively influences psychological calmness and reduces post-stroke stress. Chronic anxiety increases cortisol by 30%, suppresses immunity, and elevates inflammation, worsening prognosis. Spiritual beliefs reduce stress (up to 30%) and help control blood pressure (up to 15%), thereby improving rehabilitation outcomes. Findings suggest that spiritual beliefs mainly contribute to anxiety reduction through meaning-making, hope, perceived support, and emotional regulation, leading to improved rehabilitation results. In recent years, attention to spiritual dimensions of health alongside physical, psychological, and social aspects has increased. Conclusion. Spirituality serves as a source of meaning, hope, tranquility, and resilience, and plays a significant role in patients’ adaptation to chronic illness. However, research on spirituality in stroke rehabilitation remains limited.